Comprehensive Vial Processing System: Wash, Sterilize, Fill, and Seal

At the core of our aseptic filling machine, collection lies a crucial component – our range of vial filling machines. Designed to accommodate both small-scale and large-scale batch requirements, these filling machines serve impeccably in product development as well as clinical studies. Whether you are engaged in full-fledged commercial production or contributing to vital vaccination initiatives, our production lines are meticulously engineered to span output capacities ranging from 150 to 600 units per minute (equivalent to 9,000 to 36,000 units per hour), offering unparalleled adaptability to meet your specific needs

Our cutting-edge automatic vial filling equipment is meticulously designed to be used in ISO classified areas adhering strictly to the pharmaceutical needs & demands. The versatility of application across the pharmaceutical sector is striking: ranging from vaccines and biologics to cell and gene therapies, our equipment facilitates the filling process for single-dose as well as multi-dose products.

We are a vial and ampoule line manufacturer, producing a wide range of equipment and accessories for vial processing that include vials, ampoules, washing machine for bottles, etc. that each undergo thorough inspection for quality. Our products proudly bear the CE certification, attesting to their conformity with rigorous European standards. Additionally, they meet the stringent criteria of EU-GMP, US-FDA, and WHO compliance, further substantiating their excellence and reliability.

This dynamic adaptability empowers F Plus lines to facilitate aseptic operations or handle toxic materials up to the challenging level of OEB5 or BSL2, affirming our commitment to delivering solutions that transcend conventional boundaries.

From Start to Finish: The Vial Filling and Stoppering Sequence

Washing:

Within our aseptic framework, vials are introduced via buffer, and then subjected to thorough washing and sterilisation. F Plus’s optimised washing, a standard borne from rigorous research & development and rigorous testing, ensures 3-log cleaning, followed by efficient drying before vials proceed to sterilisation.

Sterilising:

Our advanced sterile tunnel ensures thorough yet gentle sterilisation, accompanied by exceptional accessibility for easy cleaning. Developed by F Plus, this innovative tunnel employs gradual heating from entry to sterilisation zones, minimizing temperature differentials for precise treatment. This approach prevents overkill, upholding process efficiency. The inclusion of high-end sterile filters further solidifies our commitment to top-tier quality.

Filling:

Exemplifying versatility, F Plus’s automatic vial fillers accommodate a wide array of liquid & dry powder products – from vaccines, viral vectors to biopharmaceuticals and veterinary items. Our machines handle diverse consistencies, from thin to viscous, including solutions and suspensions. Whether it is water-like substances, WFI-based products, or cold filling requirements, our vial fillers ensure safe and efficient processing with filling efficiency of +1%.

Closing

Our commitment extends to impeccable closure, safeguarding pharmaceutical purity and ensuring both flexibility and reliability. F Plus’s systems handle varied rubber stoppers, even embracing modern push-fit closures. For optimal adaptability, we streamline closure formats, enhancing cleaning convenience by eliminating vacuum control. Maintenance is equally hassle-free, thanks to smart ergonomics and accessible components.

Freeze Drying

Enhancing stability, freeze-drying preserves active ingredients in liquid medicines, prolonging shelf life without compromising efficacy.

Our expertise in integrating freeze-drying spans numerous lines. We tailor the process intricacies—mechanical and electrical integration—to each project’s specific needs.

The synergy of a combined liquid and lyo line offers a space-efficient freeze-dry connection. This innovation simplifies isolator complexity, streamlining the transition from freeze drying to liquid filling and reducing setup times.

Sealing

Sealing liquid pharmaceuticals offers dual choices: on one line or on a separate compact machine. Our capping meets EU GMP Annex 1, an F Plus’s standard. Our approach expedites changeovers, enhances fault detection, and curtails risk. Ill-fitting stoppers are screened out pre-sealing.

We are among the leading industries at the forefront of vial bulk processing technology and innovation. Opt for F Plus, the premier yet economical choice – acclaimed for efficient productivity, swift setup, and seamless maintenance. Uninterrupted line availability is our pledge, spanning the entire lifecycle of our machines.

Our line of offering are as follows:

1. High Speed Vial/Ampoule  (Combo Model): ASFC series

• Suitable for filling range of 1ml to 25 ml ampoules & 2ml to 30 ml vials
• Servo based
• No ampoules/No vials- No filling System
• 21 CFR Part-11 compliant
• IPC SCADA system compliant
• Design for Isolators, Open & Closed RAB System
• Output 150|300|400|600/min
• Certificate: CE, ATEX
• Compliance: 21 CFR Part 11, cGMP, GAMP5

2. High Speed Injectable Powder: APF Series

• Suitable for filling range of 5ml to 100 ml Vials
• 50 mg to 1500 mg single dose (with the help of change parts)
• 1500mg to 6000mg double, triple, four doses
• Servo based
• No vials- No filling System
• 21 CFR Part-11 compliant
• IPC SCADA system compliant
• Design for Isolators, Open & Closed RAB System
• Output 120/minute & 240/minute
• Certificate: CE, ATEX
• Compliance: 21 CFR Part 11, cGMP, GAMP5

3. High Speed Ampoule: ASF series

• Suitable for filling range of 1ml to 25 ml ampoules.
• Servo based
• No ampoules-No filling System
• 21 CFR Part-11 compliant
• IPC SCADA system compliant
• Design for Isolators, Open & Closed RAB System
• Output 150|300|400|600/min
• Certificate: CE, ATEX
• Compliance: 21 CFR Part 11, cGMP, GAMP5

And many more…..

At F Plus Healthcare Technologies, we manufacture & supply various equipment for pilot & production scale injectables, namely Dry Powder Injectables, Ampoule Line, Vial Line, Oral dry powder line, Injectables (Vials/Ampoules/PFS), Lyophilizers (Lyo), Depyrogenation tunnel & its peripheral equipment, to our customers located across the globe in Thailand, Vietnam, Russia, Philippines, Turkey, KSA, Iran, Iraq, Palestine, Syria, UAE, Algeria, Russia and many more.

Manufacturer and supplier of equipment for injectables production such as ampoule line, oral dry powder line, vial line, dry powder injectables, lyophilizers.

To learn more, contact us at [email protected] or on WhatsApp/Line/Viber/Telegram at +91-7506217809.